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. Author manuscript; available in PMC: 2010 Aug 20.
Published in final edited form as: Org Lett. 2009 Aug 20;11(16):3774–3776. doi: 10.1021/ol901448n

Table 3.

Olefinic-Lactam Cyclizations

graphic file with name nihms134641f6.jpg
entry amide n enamide yielda C:Ab
1 12 3 16 82% >95:5
2 20 1 22 75% 87:13
3 21 2 23 78% 90:10
a

combined yield of cyclic and acyclic enamine

b

ratio determined by 1H NMR of the crude reaction mixture