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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Biopolymers. 2010 Mar;93(3):237–251. doi: 10.1002/bip.21319

Figure 5.

Figure 5

Simplified kinetic scheme depicting the inhibition of reassocation and refolding reactions by the presence of the nucleotide free form of the GroEL chaperonin protein (GroEL sink). The actual partitioning reaction is definitely more complicated due to the presence of multiple forms (multiple landscape model) of folded, dissociated and unfolded forms of TTR. The reactions leading to fibril formation or general aggregation also illustrate the multiplicity of reactions that are present during misfolding reactions.