Table 3.
Correlations Between Patient-Reported Measures and Continuous Clinical Measures
PRO Measure | Clinical Measure | Zero-Order Correlation (95% CI) | Adjusted Correlation (95% CI) |
---|---|---|---|
EuroQol VAS | Peak VO2 | 0.094 (0.052 to 0.135) | 0.137 (0.096 to 0.179) |
Six-minute walk | 0.112 (0.071 to 0.153) | 0.137 (0.095 to 0.178) | |
KCCQ overall score | Peak VO2 | 0.213 (0.173 to 0.252) | 0.222 (0.177 to 0.265) |
Six-minute walk | 0.271 (0.232 to 0.308) | 0.278 (0.235 to 0.32) | |
KCCQ clinical summary | Peak VO2 | 0.282 (0.244 to 0.320) | 0.274 (0.233 to 0.315) |
Six-minute walk | 0.322 (0.285 to 0.358) | 0.317 (0.276 to 0.357) | |
KCCQ subscales | |||
Physical limitation | Peak VO2 | 0.309 (0.271 to 0.346) | 0.293 (0.252 to 0.334) |
Six-minute walk | 0.345 (0.309 to 0.381) | 0.330 (0.288 to 0.369) | |
Total symptom | Peak VO2 | 0.207 (0.168 to 0.246) | 0.207 (0.164 to 0.248) |
Six-minute walk | 0.244 (0.205 to 0.282) | 0.239 (0.197 to 0.28) | |
Social limitation | Peak VO2 | 0.152 (0.111 to 0.193) | 0.162 (0.118 to 0.205) |
Six-minute walk | 0.209 (0.169 to 0.248) | 0.216 (0.172 to 0.26) | |
Self-efficacy | Peak VO2 | 0.049 (0.008 to 0.090) | 0.031 (−0.011 to 0.072)† |
Six-minute walk | 0.047 (0.006 to 0.088) | 0.028 (−0.014 to 0.07)‡ | |
Quality-of-life | Peak VO2 | 0.101 (0.060 to 0.142) | 0.139 (0.094 to 0.183) |
Six-minute walk | 0.166 (0.126 to 0.206) | 0.194 (0.149 to 0.237) |
Abbreviations: PRO, patient-reported outcome; CI, confidence interval; VAS, Visual Analog Scale; peak VO2, peak oxygen consumption during cardiopulmonary exercise testing; KCCQ, Kansas City Cardiomyopathy Questionnaire.
Partial correlation coefficient after adjusting for significant patient characteristics listed in Table 1. All correlations are significantly different from zero with P < .05 except where noted.
Significantly different from zero (P = .15).
Significantly different from zero (P = .20).