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. 2009 Jun 5;1(6):503–510. doi: 10.18632/aging.100057

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Copyright: ©2009 Trinei et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — P66^Shc/ROS signals to specific functions that improve fitness whilst these same functions may increase disease risk chronically (such as obesity related disorders) and contribute to trigger p66^Shc-mediated cell death. Then, increased disease risk and cell loss rate contribute to aging dysfunctions.