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. Author manuscript; available in PMC: 2010 Jan 13.

Published in final edited form as: Clin Lymphoma Myeloma. 2009 Jun;9(3):206–216. doi: 10.3816/CLM.2009.n.042

A. The classical RS cell is binucleate, each nucleus contains a prominent eosinophilic nucleolus with perinucleolar halos giving the cell an “owl-eye” appearance (H&E). B. The LP cell, the neoplastic cell in NLPHL, has a multilobate/folded nucleus with smaller basophilic nucleoli giving the cell a “popcorn” appearance (H&E).

A. The classical RS cell is binucleate, each nucleus contains a prominent eosinophilic nucleolus with perinucleolar halos giving the cell an “owl-eye” appearance (H&E). B. The LP cell, the neoplastic cell in NLPHL, has a multilobate/folded nucleus with smaller basophilic nucleoli giving the cell a “popcorn” appearance (H&E).