Table 2.

Salient Histopathologic Features of Hodgkin lymphoma

Subtype	Salient histopathologic features
NLPHL	LP cells Background of small lymphocytes in a nodular or nodular and diffuse pattern (nodular pattern must be present at least focally). Background small B-cells with mantle cell phenotype (IgD+, IgM−). Expanded meshworks of FDCs, as seen by CD21 immunostain Epithelioid histiocytes are present in varying numbers
LRCHL	Classical HRS cells few in number. Most often nodular. HRS cells found in marginal/mantle zone around regressed GCs with dense FDC networks). May show aggregates of epithelioid histiocytes, but eosinophils and neutrophils are rare.
MCCHL	Diffuse lymph node effacement with numerous HRS cells; mixed inflammatory background with lymphocytes, eosinophils, plasma cells, histiocytes. Granulomas may be present.
LDCHL	Diffuse fibrosis variant - Hypocellular background and abundant disordered non-birefringent fibrosis, abundant histiocytes but fewer lymphocytes. Reticular variant - Numerous HRS cells with bizarre cytological features.
NSCHL	Capsular fibrosis and broad collagen bands, often perivascular Lacunar cells and mummified cells Grades I and II differ in number of HRS cells and presence of necrosis in latter.