Table 3.

Comparison of LP and HRS cells

	LP cell	HRS cells
Nucleus	Polylobated with finely dispersed chromatin	Single to multilobated with peripherally condensed chromatin
Nucleoli	Small, usually basophilic	Large, often eosinophilic
Cytoplasm	Relatively sparse	Abundant
CD15	Negative	Membrane and/or Golgi positivity
CD30	Negative; rare weak positive cells	Membrane and/or Golgi positivity
CD20	Positive	Variable (30–40% cases +)
CD79a	Positive	Negative to variably weak
CD45	Positive	Negative
J-chain	Positive	Negative
OCT 2	Positive	Often negative
BOB.1	Positive	Often negative
PU.1	Positive	Negative
PAX5	Positive	Positive (weak)
EBV	Negative	Variably positive