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. 2009 Nov 5;298(1):G45–G56. doi: 10.1152/ajpgi.00349.2009

Fig. 5.

Fig. 5.

Intraperitoneal PYY-induced suppression of colonic secretory motor response to 5-hydroxytryptophan (5-HTP) through Y2 receptor in conscious mice. A: 30-min FPO after PYY, Y1 agonist, [Leu31,Pro34]NPY, and Y2 agonist, PYY3–36 (8 nmol/kg), or saline were injected intraperitoneally 10 min before 5-HTP (10 mg/kg ip); n = 7–10/group. *P < 0.05 vs. saline-saline; #P < 0.05 vs. saline-5-HTP. B: diarrhea score from the same mice in A. *P < 0.05 vs. saline-saline; #P < 0.05 vs. saline-5-HTP. C: PYY-induced suppression of 30-min stimulated defecation induced by intraperitoneal 5-HTP in mice, with reversal by the Y2 antagonist, BIIE0246. BIIE0246 (5 mg/kg) or vehicle was injected intraperitoneally at 20 min before and PYY3–36 (8 nmol/kg) 10 min before 5-HTP (10 mg/kg) or saline in mice (n = 6–10/group). Data are means ± SE *P < 0.05 vs. vehicle-saline-5-HTP; #P < 0.05 vs. vehicle-saline-5-HTP.