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Intraperitoneal PYY3–36 inhibits gastric emptying of solid food (A), distal colonic transit (B), and defecation (C) monitored simultaneously in fasted/refed mice. Peptides, Y1 agonist [Leu31,Pro34]NPY (Y1), PYY3–36 (8 nmol/kg), or saline was injected intraperitoneally after 1-h refeeding in mice fasted overnight. Data are means ± SE of n = 7–8/group; *P < 0.05 vs. saline.
