Table 1.

Parameters of glucose homeostasis after fat feeding and weight gain

	Control	After Weight Gain
IVGTT
Kg/min−1 (× 10−2)	3.3±0.3	3.7±0.4
DI	2,946±498	2,917±353
SI, μU·ml−1·min−1	5.8±0.7	4.1±0.5*
AIRg, μU·ml−1·min	497±50	719±47**
C-peptide0-10 min, pM·min	4,306±390	6,837±554**
Euglycemic hyperinsulinemic clamp
SI, dl·kg−1·min−1·pM−1 (× 10−4)	7.1±0.8	5.2±0.5†
SI EGP, dl·kg−1·min−1·pM−1 (× 10−4)	1.0±0.2	0.7±0.1
SI Rd, dl·kg−1·min−1·pM−1 (× 10−4)	5.9±0.6	4.4±0.5†
FFA suppression, ΔmM	0.53±0.06	0.48±0.07
Hyperglycemic clamp
β-Cell function, pM·mg−1·dl−1	4.8±0.5	6.2±0.5*

Values are means ± SE. IVGTT, intravenous glucose tolerance test; DI, disposition index; S_I, insulin sensitivity; AIR_g, acute insulin response to glucose; EGP, endogenous glucose production; R_d, glucose disappearance; FFA, free fatty acids.

^*P < 0.05,

^**P < 0.01, and

^†P = 0.05.