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Effect of neuromuscular blockade by α-bungarotoxin on the responses to capsaicin in control and DM rats. α-Bungarotoxin was administered iv before iu administration of capsaicin. α-Bungarotoxin blocked EUS-EMG activity but did not alter the effects of capsaicin on smooth muscle activity in either control or DM rats. Once again, capsaicin inhibited bladder contractions and resulted in subsequent LFOs in control rats (left), but not in DM rats (right).
