Fig. 1.

Effects of captopril and ANG II infusion protocols on mean arterial pressure (MAP) and urine output. Rats were sequentially infused with 4.0% BSA in 0.9% saline (50 μl/min) for >30 min, then with captopril (12 μg/min) for 20 min, and then with ANG II + captopril (20 ng·kg⁻¹·min⁻¹ ANG II and 12 μg/min captopril). A: MAP was measured continuously at the carotid (mmHg). B: urine was collected continuously in 10-min intervals and output rate was averaged over the treatment period (mg/min), n = 10, individual traces and means ± SE.