Fig. 6.

Afferent arteriole average diameter responses (delta % of baseline) to ANG I (0, 1, 10, 100 nM) in the presence of AT₁ receptor blockade (A; n = 6, 7), ACE inhibition (B; n = 6, 6), serine protease inhibition (C; n = 6, 6), or combined ACE and serine protease inhibition (D; n = 7, 6) in kidneys of control (□) and diabetic (·) mice. Afferent arteriole vasoconstriction produced by ANG I was significantly attenuated by AT₁ receptor blockade, ACE inhibition, combined ACE and serine protease inhibition, but not by serine protease inhibition alone in kidneys of control mice. Afferent arteriole vasoconstriction produced by ANG I was significantly attenuated by AT₁ receptor blockade, serine protease inhibition, and combined ACE and serine protease inhibition, but not by ACE inhibition alone in kidneys of diabetic mice. *P ≤ 0.05 vs. baseline diameter. †P ≤ 0.05 control vs. diabetic. #P ≤ 0.05 vs. ANG I alone.