Fig. 9.

Diagram of the pathway linking ouabain with Na⁺ pump α₂-subunits, NCX1, TRPC1, and TRPC6 expression, upregulation of [Ca²⁺]_cyt and Ca²⁺ signaling, and their likely effects on vascular tone and blood pressure. Several known interactions, including those elucidated in this report, are indicated by solid arrows (outside the boxes). Links that have not been clarified and that require further investigation are indicated by dashed arrows. To focus on this proposed pathway, a variety of feedback regulatory mechanisms have been omitted. [Na⁺]_cyt, cytosolic free Na⁺ concentration.