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EP4-dependent PGE2 signaling in NVMs. This schematic summarizes our data related to PGE2 and EP4 signaling in NVMs. EP4 acting through cAMP and PKA activates the small GTPase Rap. Downstream of Rap is ERK1/2 and p90RSK. p90RSK acts to stimulate the expression of c-Fos, Egr-1, and BNP. Other EPs (in particular, EP3) may act at the level of activation of ERK1/2.
