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. 2009 Oct 28;298(1):C38–C45. doi: 10.1152/ajpcell.00315.2009

Fig. 1.

Fig. 1.

Forkhead box subfamily O 3A (FOXO3a) signaling is required for disuse muscle fiber atrophy. A and B: representative cross sections taken from the soleus muscle of weight-bearing (A) and 7-day-immobilized (Imm) rats (B), each injected with dominant-negative (d.n.)FOXO3a + enhanced green fluorescent protein (EGFP). The cross-sectional area of green fluorescent fibers (fibers expressing d.n.FOXO3a) was measured and compared with the cross-sectional area of nonfluorescent fibers (fibers not expressing d.n.FOXO3a) within the same muscle. C: muscle fiber cross-sectional area of ∼250 fibers/muscle, from 6 muscles/group. D: frequency distribution of the fiber areas from weight-bearing muscles, immobilized muscles, and immobilized muscles expressing d.n.FOXO3a + EGFP. *P < 0.05 vs. nonexpressing weight-bearing fibers; †P < 0.05 vs. nonexpressing immobilized fibers.