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. 2009 Oct 28;298(1):C38–C45. doi: 10.1152/ajpcell.00315.2009

Fig. 4.

Fig. 4.

FOXO3a induces MuRF1 through a DNA-binding independent mechanism. A: relative luciferase activity from soleus muscles 4 days following injection with a MuRF1 promoter-reporter plus WT FOXO3a and Hsp70 or the respective control plasmids. B–D: relative luciferase activity from soleus muscles 4 days following injection with a MuRF1 promoter-reporter (B), an atrogin-1 promoter-reporter (C), or a DAF-16 reporter (D), plus a FOXO3a DNA-binding mutant (FOXO3a DBM) or the respective control plasmid. Each bar represents the mean ± SE from at least 8 muscles. *Significantly different from control-injected group (P < 0.05).