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. 2003 Nov 1;17(21):2709–2720. doi: 10.1101/gad.1136603

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Copyright © 2003, Cold Spring Harbor Laboratory Press

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Figure 6. — Blockage of Hh signaling by Cos2 deletion mutants. (A,A′) A wing disc expressing UAS-HA-Cos2ΔN2 by act > CD2 > Gal4 was immunostained for ptc-lacZ (green) and HA (red). Cos2ΔN2 blocks the expression of ptc-lacZ near the A/P border (arrows). (B) A wing disc expressing UAS-HACos2CC by act > CD2 > Gal4. Cos2CC failed to suppress ptc-lacZ expression at the A/P compartment boundary (arrows). (C-C″) A wing disc expressing both UAS-HA-Cos2ΔN2 and UAS-GFP-Smo by act > CD2 > Gal4 was immunostained to show the expression of HA (red), ptc-lacZ (green), and GFP (blue). Coexpression of GFP-Smo with Cos2ΔN2 restores the expression of ptc-lacZ near the A/P border (arrows). (D-D″) A wing disc expressing UAS-Flag-Cos2CT1 by MS1096 was stained to show the expression of Flag (red), ptc-lacZ (green), and En (blue). High levels of Cos2CT1 suppress the expression of ptc-lacZ and en (arrows). A wild-type adult wing (E) or adult wing expressing UAS-Flag-Cos2CT1 by MS1096 (F). Overexpressing Cos2CT1 results in wing phenotypes similar to those caused by the fu mutation.