Fig. 1.
Means ± SE percent change in bicycle ergometry, MRS, and in vitro skeletal muscle biopsy data from Wtinitial. Maintenance of a reduced body weight (Wt−10%) is associated with a significant reduction in the respiratory exchange ratio (RER) during low-level exercise (bicycling to generate 10–25W of power) and muscle phosphofructokinase (PFK) and ratio of PFK/cytochrome c oxidase (COX). Maintenance of an elevated body weight (Wt+10%) is associated with a significant increase in RER during low-level exercise (bicycling to generate 10 W of power). HADH, 2-hydroxyacyl CoA dehydrogenase activity. *P < 0.05 compared with zero.