Figure 9.

Summary of the major findings. The changes of glutamate cysteine ligase (GCL) activity and protein content for the catalytic subunit of glutamate cysteine ligase (GCLC) and modifier subunit of glutamate cysteine ligase (GCLM) in adult (top) and old (bottom) rats are plotted to demonstrate the relationship of these variables with the changes of reduced glutathione (GSH) content. Values are relative to control for each age. c = weight bearing; 3d, 7d, and 14d = hind-limb unloading for 3, 7, and 14 days. *Drawn from the data in Chen and colleagues (3).