Table 2.

PRNP gene sequence variation in sCJD cases and controls

PRNP Variation	309 sCJD Patients	192 UK DNA Controls	778 Scottish Blood Donor Controls
Codon 129 (Met/Val)	MM (n = 184; 59.5%) MV (n = 66; 21.4%) VV (n = 59; 19.1%)	MM (n = 90; 46.9%) MV (n = 87; 45.3%) VV (n = 15; 7.8%)	MM (n = 337; 43.3%) MV (n = 344; 44.2%) VV (n = 97; 12.5%)
Codon 117 (Ala/Ala)	n = 13; 4.2% (10.4% of MV/VV cases)	n = 9; 4.7% (10.3% of MV/VV cases)	n = 47; 6.0% (10.7% of MV/VV cases)
24 bp Deletion	n = 4; 1.3% Deletion Class R34 (n = 3) R3 (n = 1)	n = 1; 0.5% Deletion Class R2 (n = 1)	n = 12; 1.5% Deletion Class R34 (n = 12)
Codon 167 (Asp/Gly)	DG (n = 1; 0.32%)	(no sequence data available)	(no sequence data available)
Codon 68 (Pro/Pro)	PP (n = 1; 0.32%)	(no sequence data available)	(no sequence data available)