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Treatment with a TRβI inhibitor reverses PAI-1 RNA level in TGF-β1-induced mesenchymal renal tubular epithelial cells to levels present in epithelial cells. mTEC-KOs were incubated with 100 pM TGF-β1 ligand for 72 hours, followed by the addition of 5 μM SB431542 plus 100 pM TGF-β1 for 24 hours. Cell lysates were prepared and relative PAI-1 RNA levels were determined by quantitative RT-PCR. Significant differences are indicated with an asterisk (*) (P <0.05, n = 9).
