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Model for reversal of EMT induced by TGF-β1. To re-express epithelial proteins such as E-cadherin, a TβRI kinase inhibitor is needed to decrease expression of mesenchymal genes (e.g., ZEB1 and ZEB2), while a Rho kinase inhibitor is required to stabilize the epithelial cortical actin. A p38 MAPK inhibitor may also be useful as this drug in conjunction with the TβRI kinase inhibitor can further EMT reversal by reducing stress fiber actin formation.
