Table 1.
Modena Model
| High risk | Pedigree Classification | |||
|---|---|---|---|---|
| I) at least 3 relatives diagnosed with BC (or OC) in 2 different generations | II) one BC/OC case is a first degree relative of the other 2 (of the other 1 if the first criterion is not fulfilled)° | III) at lest one case has been diagnosed at the age ≤ 40 or with bilateral BC | ||
| * | * | * | Hereditary | HBC/HBOC |
| * | * | Suspect Hereditary | SHBC/SHBOC | |
| * | * | Suspect Hereditary | SHBC/SHBOC | |
| BC diagnosed at age ≤ 35, regardless of family history |
Early onset | EOBC | ||
| BC and OC in the same woman, regardless of family history |
Breast and Ovarian Cancer | BOC | ||
| Intermediate Risk | ||||
| * | Familial | FBC/FBOC | ||
| * | * | Strongly suspected Familial | SFBC/SFBOC | |
| Male BC, regardless of family history | Male Breast Cancer | MBC | ||
| Slightly Increased Risk | ||||
| * | Suspected Familial | SFBC/SFBOC | ||
| * | Suspected Familial | SFBC/SFBOC | ||
| BC/OC without any of the described criteria | Sporadic Breast Cancer | SpBC/SpOC | ||
BC - Breast Cancer; OC - Ovarian Cancer; H - Hereditary; F- Familial; S - Suspect; s - sporadic; M - Male