Table I.
mTOR− mice exhibit reduced body weight associated with a strong reduction in the mass of fast-twitch glycolytic muscles
| Variable | Control | mTOR− | % Control |
| Body weight (g) | 17.41 ± 1.05 | 15.85 ± 1.37a | 91.0 |
| Soleus weight (mg) | 4.93 ± 0.64 | 5.00 ± 0.61 | 101.4 |
| Soleus/body weight (mg/g) | 0.28 ± 0.03 | 0.32 ± 0.03b | 114.3 |
| TA weight (mg) | 30.93 ± 3.56 | 24.54 ± 2.29a | 79.3 |
| TA/body weight (mg/g) | 1.78 ± 0.22 | 1.55 ± 0.04a | 87.1 |
| GC weight (mg) | 71.13 ± 5.23 | 56.27 ± 4.79a | 79.1 |
| GC/body weight (mg/g) | 4.09 ± 0.26 | 3.55 ± 0.07a | 86.8 |
| PLA weight (mg) | 10.81 ± 0.53 | 8.37 ± 0.85a | 77.4 |
| PLA/body weight (mg/g) | 0.62 ± 0.03 | 0.53 ± 0.06a | 85.5 |
| Liver (mg) | 868.26 ± 53.77 | 851.84 ± 102.75 | 98.1 |
| Liver/body weight (mg/g) | 50.05 ± 4.50 | 53.69 ± 3.40 | 107.3 |
| Fat pad weight (mg) | 295.78 ± 40.15 | 286.73 ± 30.12 | 96.9 |
| Fat pad/body weight (mg/g) | 16.98 ± 1.90 | 18.08 ± 1.15 | 106.9 |
| Heart weight (mg) | 120.62 ± 9.49 | 114.17 ± 9.07 | 94.7 |
| Heart/body weight (mg/g) | 6.95 ± 0.68 | 7.22 ± 0.50 | 103.9 |
Values are for 6-wk-old control and mTOR− female mice. Fat data includes ovarian, uterine, and retroperitoneal fat pads. Data indicate mean ± SD (n > 5 mice/group).
a
P < 0.01.
b
P < 0.05.