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. 2010 Jan;135(1):3–13. doi: 10.1085/jgp.200910265

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© 2009 Yang and Delay

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Isolated mouse VSNs responded to dilute urine. (A) Perforated patch clamp recordings from the soma showed inward currents induced by a 2-s application of urine at voltage steps from −100 to −40 mV (20-mV increments). The time for the urine application is shown by the dark line above current traces. DU, 1:500 dilute urine. (B) I-V plot for the urine response of the VSN shown in A. Dashed line shows the best-fit line (y = 1.1183x plus 29.118; R² = 0.9521). (C) Summary of the peak amplitudes for urine-induced inward currents at V_hold = −80 mV for 67 urine-responsive VSNs (one to two cells per mouse).