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. 2009 Dec 21;206(13):3047–3059. doi: 10.1084/jem.20090900

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© 2009 Muñoz et al.

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Figure 3. — Small intestinal immunopathology is mediated by MMP-2 but not MMP-9. (A) Relative body weight loss of WT (n = 43), MMP-9^−/− (n = 28), and MMP-2^−/− (n = 11) mice 8 d after infection. (B) Relative shortening of small intestine of WT (n = 13), MMP-9^−/− (n = 6), and MMP-2^−/− (n = 11) mice 8 d after infection. (C) Histopathology score of WT (n = 42), MMP-9^−/− (n = 17), and MMP-2^−/− (n = 11) mice 8 d after infection. Horizontal bars indicate means for each group. (D) T. gondii parasitophorous vacuoles that contained tachyzoites were stained with a rabbit anti–T. gondii IgG antibody and counted in the terminal ileum in WT, MMP-2^−/−, and MMP-9^−/− mice 8 d after infection. (E) NO levels and (F) IFN-γ concentration in supernatants of ileal biopsies from WT (n = 15), MMP-9^−/− (n = 6), and MMP-2^−/− (n = 10) mice 8 d after infection. Data are pooled from at least three independent experiments. Mean values, SDs, and significance levels were determined by the Student's t test or by Kaplan-Meier analysis and the log-rank test (A).