Table II.

Summary of the effects of the different XPD mutations

			XPD mutation
			R683W	Q452X	I455del	199insPP
DNA repair	NER
	helicase activity		±
	ATPase		+	+	+	+
	TFIIH structure	50 mM KCl	+	+	+	+
		150 mM KCl	+	+	+
	p44–XPD interaction	350 mM KCl	+		+
Transcription	RNA pol II phosphorylation		+	±
	cdk7 kinase activity		+	+	+
	basal transcription		+
	transactivation by nuclear receptors
	nuclear receptor stabilization		+	+	+	±