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. Author manuscript; available in PMC: 2010 Jan 13.
Published in final edited form as: Learn Mem. 2002 Sep–Oct;9(5):224–237. doi: 10.1101/lm.51202

Figure 1.

Figure 1

BDNF increases dendritic spine density in CA1 pyramidal neurons of hippocampal slices. Representative apical dendritic segments from CA1 pyramidal neurons from a serum-free (control; left) and a BDNF-treated hippocampal slice culture (250 ng/mL, 5–7 div; right). CA1 pyramidal neurons were filled with Alexa-594 during whole-cell recording, and later imaged by laser-scanning confocal microscopy. (Middle) Histograms of the number of dendritic spines per 10 μm of apical dendrite. The tyrosine kinase inhibitor K-252a blocked the BDNF-induced increase in dendritic spine density. Adapted from Tyler and Pozzo-Miller (2001).