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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Genesis. 2010 Jan;48(1):20–30. doi: 10.1002/dvg.20578

Figure 3. dyrk1b is maternally supplied and essential during embryonic development in the zebrafish.

Figure 3

A) RT-PCR detection of dyrk1b transcripts in unfertilized oocytes (oo), sphere stage (sph), shield stage (sh), tailbud stage (tb), 20 somites stage (20s), and 24 hours post fertilization (24h) stage animals. The rpl35 gene serves as positive control. The edn1 gene serves as negative control for detection in oocytes. B) Normal phenotype of 5-mismatch control morpholino-injected (control-MO) animals at 28hpf. Upper panel shows normal head, eye, pigment and ear development. Lower panel shows normal notochord, tail and somite development. C) Phenotype of dyrk1b antisense morpholino-injected (dyrk1b-MO) animals at 28hpf. Upper panel shows small head and eyes of the morphant animals. Lower panel shows the moderately shortened length of the tail.