Table 1.
Dose | No. of litters (N) | No. of implants (N) | No. of resorptions (%) b | No. of birth defectsd (%) c | No. of live births (N) |
---|---|---|---|---|---|
0 (vehicle) | 12 | 108 | 3 (2.8) | 1 (0.95) | 102 |
20 mg/kg | 11 | 100 | 15 (15)* | 8 (10.2)* | 77 |
Dams were injected intraperitonially on gd 7 and 8 and the fetuses examined on gd 17.5.
Percent of implants.
Percent from the total number of live born fetuses
Birth defects include NTDs, orofacial abnormalities and gastroschisis.
Significantly different when compared to vehicle treated control animals (p< 0.05).