Fig. 4.

Lens fibre cell differentiation is not affected in aPKCλ cko lenses. In control lens (A–C), CP49 was expressed in fibre cells, but not in lens epithelial cells. CP49 expression was maintained in aPKCλ cko lenses (D–F), although the fibre cell alignment was disrupted and the signal at the plasma membranes is not as strong as in controls. E-cadherin is normally expressed in the lens epithelial cells and is lost at the equator when the cells initiate fibre differentiation (G–I). A similar differentiation-associated decrease of E-cadherin expression was detected in aPKCλ cko lenses (J–L) as is observed in control lenses. LE, lens epithelial cell; LF, lens fibre cell. Scale bar shows 50 μm.