Fig. 7.

A postmitotic marker is ectopically induced in proliferation zone of aPKCλ cko lens (E16.5). p57/Kip2 is a cyclin-dependent kinase inhibitor expressed in postmitotic cells. In control lens (A–C, G–I), Kip2 was induced just anterior (white asterisks) to the equator (arrows) where the lens epithelial cells withdraw from their cell cycle and begin to differentiate into fibre cells. In aPKCλ cko lenses (D–F, J–L), Kip2 was detected more anterior to the equator (yellow asterisks). Scale bars: 100 μm in (A) to (F) and 50 μm in (G) to (L).