Table 4.

Sensitivity analyses altering the definition of p53 positivity.

	Original a priori definition a	More stringent definition b	Less stringent definition c
Long duration of Cigarette Smoking (30+ years)
No p53 protein overexpression	1.8 (1.1–2.9)	1.8 (1.1–2.9)	2.1 (1.1–4.3)
p53 protein overexpression	1.0 (0.4–2.6)	0.9 (0.3–2.7)	1.4 (0.8–2.4)
Case/Case Comparison	0.6 (0.2–1.5)	0.5 (0.2–1.6)	0.6 (0.3–1.4)
Heavy Beer Consumption (8 + bottles per week)
No p53 protein overexpression	1.6 (0.7–3.7)	1.5 (0.7–3.5)	2.4 (0.9–6.5)
p53 protein overexpression	4.0 (1.3–12.0)	4.9 (1.5–15.8)	1.8 (0.8–4.3)
Case/Case Comparison	2.5 (0.7–8.1)	3.2 (0.9–11.1)	0.8 (0.3–2.3)

^aOriginal definition: intensity score of strong and at least 10% or more of cells showing evidence of overexpression ^bMore stringent definition: intensity score of strong and at least 25% or more of cells showing evidence of overexpression ^cLess stringent definition: intensity score of moderate or strong and at least 10% or more of cells showing evidence of overexpression