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| Systemic risk factors for PVT (30%) |
| Inherited |
| Factor V Leiden mutation |
| Factor II (prothrombin) mutation |
| Protein C deficiency |
| Protein S deficiency |
| Antithrombin deficiency |
| Acquired |
| Myeloproliferative disorder |
| Antiphospholipid syndrome |
| Paroxysmal nocturnal hemoglobinuria |
| Oral contraceptives |
| Pregnancy or puerperium |
| Hyperhomocysteinemia |
| Malignancy |
