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. 2009 Nov 30;187(5):669–683. doi: 10.1083/jcb.200906014

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© 2009 Rucci et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Effect of ^hbdPRELP in vivo. Ovariectomized (OVX) mice were treated with vehicle, 10 mg/kg body weight of ^hbdPRELP, or control peptide and 1 mg/kg body weight of alendronate as reference drug 5 d/wk for 5 wk. (A) Quantification of the bone resorption marker CTX in urine samples. (B) Tibial sections stained for TRAcP activity (purple stain) to evidence osteoclasts. (C–H) Measurement of osteoclast number/bone surface (OcN/BS; C), osteoclast surface/bone surface (OcS/BS; D), bone volume/tissue volume (BV/TV; E), trabecular number (Tb N; F), trabecular thickness (Tb Th; G), and trabecular separation (Tb Sp; H). (A and C–H) Data are the mean ± SD of five mice per group (*, P < 0.05 vs. sham; ^#, P < 0.05 vs. control peptide and vehicle; and ⁺, P < 0.05 vs. control peptide).