Table 1.
PI3K expression patterns in normal human tissues.
| Human Tissues | n | Histological Structure | p85 | PI3K-C2α | PI3K-C2β | Figure |
| Digestive system | ||||||
| Stomach | 3 | Peptic (chief) cells | +++ | ++ | ++ | 2A |
| Parietal (oxyntic) cells | - | - | - | |||
| Gastric mucous cells | - | - | - | |||
| Small intestine | 7 | Enterocytes | +++ | ++ | + | 2B |
| Paneth cells | ++ | - | - | |||
| Goblet cells | - | - | - | |||
| Colon | 10 | Colonocytes | ++ | ++ | ++ | 2C |
| Goblet cells | - | - | - | |||
| Features common to all GIT | Mononuclear cells | +++ | ++ | +++ | 2D | |
| Muscular layers | - | ++ | - | |||
| Ganglion cells | +++ | - | +++ | 2E | ||
| Non-myelinated nerves | - | - | ++ | 2E | ||
| Neuroendocrine cells | - | - | - | |||
| Respiratory system | ||||||
| Lung | 5 | Pneumocytes (Types I and II) | - | - | - | |
| Alveolar Macrophages | ++ | ++ | ++ | 2F | ||
| Bronchi | Bronchial Epithelium | + | + | + | ||
| Bronchial glands | - | - | - | |||
| Cartilage | - | - | - | |||
| Bronchial smooth muscle | - | ++ | - | |||
| Skin and Integument | 5 | Stratified squamous epithelium | - | - | - | 2G |
| Melanocytes | - | - | - | |||
| Sebaceous glands | + | - | - | 2G | ||
| Hair follicle | + | - | - | 2H | ||
| Sweat Glands | + | + | - | 2H | ||
| Langerhans cells | ++ | - | - | 2I | ||
| Dermal macrophages | ++ | ++ | ++ | 2I | ||
| Female reproductive system | ||||||
| Uterus | 3 | Proliferative Endometrium | ++ | - | - | 2J |
| 3 | Secretory Endometrium | + | - | - | 2K | |
| Endometrial Stroma | - | - | - | |||
| Myometrium | - | ++ | - | |||
| Cervix | 3 | Ectocervical squamous epithelium | - | - | - | |
| Endocervical glands | - | - | - | 2L | ||
| Cervical smooth muscle | - | ++ | - | |||
| Ovary | 3 | Follicular cells | ++ | + | + | 2M |
| Germinal cells | - | - | - | |||
| Stromal cells | - | - | - | |||
| Corpus luteum | ND | ND | ND | |||
| Fallopian tube | 2 | Columnar ciliated epithelium | +++ | ++ | + | 2N |
| Mammary gland (breast) | 3 | Luminal acinar epithelium | - | - | - | 2O |
| Myoepithelial cells | - | + | - | |||
| Lactiferous ducts | - | + | - | |||
| Male reproductive system | ||||||
| Testis | 3 | Spermatogenic cells | +++ | - | +++ * | 2P, 2Q * |
| Sertoli cells | - | - | - | |||
| Leydig cells | ++ | +++ | ++ | |||
| Prostate gland | 10 | Basal Epithelium | - | + | - | |
| Luminal epithelium | - | - | - | |||
| Fibromuscular stroma | - | ++ | - | |||
| Urinary system | ||||||
| Urinary bladder | 5 | Transitional epithelium | ++ | ++ | ++ | 2R |
| Muscularis | - | ++ | - | |||
| Kidney | 10 | Glomerular macrophages | ++ | - | ++ | 3A |
| Glomerular tuft | - | +++ | - | 3B | ||
| Proximal Tubules | - | + | + | |||
| Macula Densa | ++ | - | - | 3A | ||
| Distal tubules | - | + | + | |||
| Collecting tubules | +++ | + | + | |||
| Pancreas | 5 | Acini | +++ | ++ | - | 3C, 3D |
| Ducts | - | ++ | - | 3D | ||
| Islets of Langerhans | - | - | - | 3C | ||
| Hepatobiliary system | ||||||
| Liver | 4 | Hepatocytes | - | - | - | |
| Bile ducts | - | ++ | - | |||
| Kupffer cells | - | - | - | |||
| Gall bladder | 4 | Lining epithelium | + | + | + | |
| Smooth muscle layer | - | ++ | - | |||
| Mononuclear cells | ++ | ++ | ++ | |||
| Endocrine System | ||||||
| Thyroid | 3 | Follicular/Parafollicular | - | - | - | |
| Parathyroid | 3 | Oxyphil/Chief | - | - | - | |
| Endocrine Pancreas | Islets of Langerhans | - | - | - | ||
| Lymphoid tissue & Immune cells | ||||||
| Spleen | 5 | White pulp | - | - | - | |
| Red pulp (mononuclear cells) | ++ | + | ++ | 3E | ||
| Red pulp (splenic sinusoids) | - | +++ | - | 3F | ||
| Lymph nodes | 5 | Lymphoid follicles | - | - | - | |
| Germinal centre mononuclear cells | ++ | + | + | |||
| Medulla (mononuclear cells) | ++ | + | ++ | |||
| Tissue macrophages | +++ | ++ | ++ | 3G | ||
| Polymorphnuclear leucocytes | + | +++ | - | 3H | ||
Abbreviations and symbols used: ND: Not determined; - undetectable; + weak; ++ moderate or +++ strong. Reactivity for PI3K-C2α in venous and capillary endothelium was not included in the tissue staining results. *Expression of PI3K-C2β was nuclear in spermatocytes.