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. 2009 Nov 23;206(12):2685–2699. doi: 10.1084/jem.20092024

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© 2009 The Rockefeller University Press

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Figure 2. — Ets1^−/− MHC I–restricted thymocytes fail to down-regulate CD4 during the late stages of positive selection. (A) Thymocytes from Ets1^+/+ (top) or Ets1^−/− (bottom) mice carrying the P14 TCR transgene were assessed for expression of CD4, CD8, CD24, and the transgenic Vα2 TCRα chain. Two-parameter contour plots of CD4 and CD8 expression (left) show a reduced frequency of CD8 SP cells in Ets1^−/− thymi. The Vα2^hi CD24^lo subset is defined on two-parameter contour plots of CD24 and Vα2 expression (middle), and analyzed for CD4 and CD8 expression (right). Data are from more than three experiments. (B) Bar graphs (mean ± SEM) represent the absolute numbers of thymocytes within each mature (Vα2^hi CD24^lo) subset. Total thymocyte numbers (average ± SEM; × 10⁻⁶; n = 7) were 111 ± 23 and 43 ± 4.8 in Ets1^+/+ and Ets1^−/− P14 mice, respectively.