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. 2009 Nov 23;206(12):2625–2639. doi: 10.1084/jem.20091320

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© 2009 Yin et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Models of H2AX function during end-joining repair of chromosomal DSBs. Schematic diagrams depicting the potential positional stability of broken chromosomal DNA strands during V(D)J recombination, CSR, or general DSB repair in G1-phase wild-type and H2AX-deficient cells. Boxes and triangle represent RAG-generated coding and signal ends, respectively. H2AX-mediated stabilization of broken DNA strands would be dispensable for end joining during V(D)J recombination as a result of DNA end stabilization by ATM/MRN and RAG postcleavage synaptic complexes. However, this H2AX function would be important for end joining during CSR and general DSB repair.