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Clinically identified inhibitor-resistant SHV β-lactamasesa
| β-Lactamase | Amino acid at positionb: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 35 | 69 | 130 | 140 | 146 | 187 | 192 | 193 | 234 | 238 | 240 | |
| SHV-1 | Leu | Met | Ser | Ala | Ala | Ala | Lys | Leu | Lys | Gly | Glu |
| SHV-10 | Gly | Arg | Asn | Val | Ser | Lys | |||||
| SHV-26 | Thr | ||||||||||
| SHV-49 | Ile | ||||||||||
| SHV-56 | Gln | Arg | |||||||||
| SHV-72 | Val | Arg | |||||||||
Based on data from www.lahey.org/studies/webt.asp.
Unless otherwise indicated, the amino acid is the same as in the non-IR SHV-1.
