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. 2009 Dec 29;107(1):75–80. doi: 10.1073/pnas.0912589107

Fig. 5.

Fig. 5.

Expansion of ALDH1-expressing centroacinar and terminal ductal epithelial cells in setting of chronic inflammation and regenerative epithelial metaplasia. Following antigen retrieval, ALDH1 protein was detected using immunohistochemistry on pancreatic tissue from normal adult pancreas (A and B) and pancreas harvested from mice with chronic pancreatitis induced by three weekly injections of caerulein (C–H). (A and B) Low-frequency labeling for ALDH1 in terminal ductal (TD) epithelial cells from normal adult pancreas. (C and D) Expansion of ALDH1-expressing terminal ductal epithelium following sequential caerulein administration. (E and F) Similar expansion of ALDH1-expressing centroacinar cells (CAC) following sequential caerulein administration. (G and H) Expression of ALDH1 in caerulein-induced metaplastic type 2 (TC2; H), but not type 1 (TC1; G) tubular complexes.