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. 2009 Dec 29;107(1):228–233. doi: 10.1073/pnas.0906112107

Fig. 1.

Fig. 1.

Changes in tight junction proteins and TER. (A) Pathways containing differentially expressed genes involved in tight junction formation were adapted from Pathway Express using KEGG classifications. Red, up-regulation; blue, down-regulation; gray, no change in expression; arrow, molecular interaction leading to activation; blunt line without an arrowhead, molecular interaction leading to inhibition. The pathway scheme shown is based on microarray data and does not include posttranscriptional regulation. (B) Changes in the TER of polarized HCT-8 cells exposed to either solvent (filled circles) or indole (open circles) for 24 h. Data represent mean ± SD from seven measurements at each time point and two independent experiments. (C) Effect of indole pretreatment on adherence of EHEC to HCT-8 cells in the presence of 500 μM norepinephrine. Data represent mean ± SD from three wells per experiment and three independent experiments. *, statistical significance, using Student's t test, at P < 0.05; **, significance at P < 0.005.