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. 2009 Dec 14;107(1):246–251. doi: 10.1073/pnas.0908428107

Fig. 1.

Fig. 1.

Noninvasive in vivo imaging in a murine model of pancreatic ductal adenocarcinoma (PDAC). (A–C) H&E staining of (A) a normal pancreatic duct in a Pdx1-Cre-GFP, LSL-Trp53R172H (PC) mouse, (B) a PanIN lesion in a Pdx1-Cre-GFP-LSL-KrasG12D, LSL-Trp53R172H (KPC) mouse, and (C) an invasive adenocarcinoma from a KPC mouse. (D) Alcian blue staining of a PanIN lesion from a KPC mouse. (E and F) In vivo imaging, using the Olympus OV100 in vivo imaging system, of GFP fluorescence within the pancreata of (E) 2-week-old and (F) 3-week-old Pdx1-Cre-GFP, LSL-KrasG12D/+ (KC) mice and PC mice, as indicated. (Top) Whole-body imaging; (Bottom) ×8 magnification of excised pancreata. (G and H) In vivo imaging, using the Olympus OV100 in vivo imaging system, of GFP fluorescence within the pancreata of (G) 4-week-old and (H) 6-week-old KC mice and PC mice, as indicated.