Fig. 3.

CD25-mediated signals are necessary for the optimal expansion of effector CD8⁺ T cells. Time course showing the percentage of Ova/K^b-specific CD8⁺ T cells (A) and B8R/K^b-specific CD8⁺ T cells (B) from the blood in mixed bone marrow chimera mice infected with 10³ CFU of LM-ova or 2 × 10⁶ PFU of VV-WR, respectively. The CD8⁺ T cell population was first divided into WT cells (blue) or CD25-deficient cells (red) and then the percentage of antigen-specific CD8⁺ T cells was monitored longitudinally in the blood.