Fig. 5.

Rabeprazole interferes with early steps of viral infection. (A) Huh-7 cells were infected (m.o.i. of 10) with D183 JFH-1 virus in the presence of rabeprazole (20 μM). Intracellular and extracellular infectivity as well as HCV RNA levels are shown as average and mean error of a representative experiment performed in triplicate and are expressed as percentage of DMSO-treated cells. (B) GFP expression reflecting subgenomic HCV replicon replication after transfection into Huh-7 cells in the presence of DMSO or 2′-C-methyladenosine (1 μM) or rabeprazole (20 μM). Data are expressed as average and mean error of at least two independent experiments performed in duplicate.