Table 1.

sAC inhibition prevents compensation of blood alkalosis in whole animals

	0			12 h
	Control	KH7	4CE	Control	KH7	4CE
pH	7.77 ± 0.02 (a)	7.82 ± 0.06 (a)	7.84 ± 0.03 (a)	7.97 ± 0.03 (b)	8.22 ± 0.06 (c)	8.12 ± 0.04 (c)
[HCO3−]	4.1 ± 0.4 (a)	3.5 ± 1.1 (a)	3.4 ± 0.6 (a)	8.3 ± 0.8 (b)	17.9 ± 3.4 (c)	17.1 ± 4.4 (c)
PCO2	1.5 ± 0.2 (a)	0.9 ± 0.2 (a)	1.2 ± 0.3 (a)	2.1 ± 0.4 (b)	2.2 ± 0.4 (b)	2.8 ± 0.6 (b)

Blood pH, plasma [HCO₃⁻] (mM), and PCO₂ (torr) of dogfish infused i.v. with NaHCO₃ (1,000 μEq·kg⁻1·h⁻¹) and injected with DMSO (control, n = 11), KH7 (n = 9), or 4CE (n = 7). KH7 and 4CE were injected as a 5-μmol·kg⁻¹ bolus at t = −0.5 and 6 h. Data were analyzed using repeated-measures two-way ANOVA. Different letters indicate significant differences (P < 0.05) within each variable using Bonferroni’s posttest (if the interaction between treatment and time was significant) and the Tukey–Kramer planned least square means test (if the interaction was not significant). A summary of the statistics is shown in Table S1.