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Mitochondrial depolarization stabilizes both the 63-kDa full-length and the 52-kDa cleaved PINK1. Western blot analysis of the cytosolic and mitochondrial fractions of HeLa cells incubated for 1 hr with vehicle (DMSO), 10 μM CCCP, 1 μM Antimycin A (AA), 1 μM Oligomycin (Oligo), or the combination of 1 μM Antimycin A plus 1 μM Oligomycin (AA+Oligo). Treatments that dissipate ΔΨm, such as CCCP and AA+O, increase the PINK1 content in the mitochondrial fraction.
