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Working model of mouse egg activation. A rise in [Ca2+]i activates the γ isoform of CaMKII that in turn triggers meiotic resumption by decreasing MAPK and MPF activity. Cortical granule (CG) exocytosis and the subsequent ZP block to polyspermy are triggered by [Ca2+]i in a CaMKII-independent manner. Maternal mRNA recruitment is elicited by [Ca2+]i and requires cell cycle resumption but does not directly depend on CaMKII.
