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. 2009 Sep-Oct;3(5):197–203.

Figure 1.

Figure 1.

5-Fluorouracil metabolism

Abbreviations: 5-FU = 5-fluorouracil; DPD = dihydropyrimidine dehydrogenase; dTMP = thymidine monophosphate; dUMP = deoxyuridine monophosphate; FDHU = 5-fluorodihydrouracil; FdU = fluorodeoxyuridine; FdUMP = 5-fluoro-2-deoxyuridine monophosphate; FdUrd = 5-fluorodeoxyuridine; FUTP = 5-fluorouridine triphosphate; MTHFR = methylenetetrahydrofolate reductase; THF = tetrahydrofolate; TK = thymidine kinase; TP = thymidilate phosphorylase; TS = thymidylate synthase