Skip to main content
. Author manuscript; available in PMC: 2010 Jan 14.
Published in final edited form as: Angew Chem Int Ed Engl. 2009;48(24):4430–4432. doi: 10.1002/anie.200900924

Scheme 1.

Scheme 1

Reagents and conditions: a) Ph3PCHCO2Et, THF, reflux, 83:17 E:Z; b) PhCH(OMe)2, CSA, DCM, 76% (2 steps); c) TBSCl, imid, DMF, 71%; d) DIBALH, DCM, 97%; e) D-(−)-DET, Ti(OiPr)4, TBHP, DCM, −25 °C, 95%, 9:1 d.r.; f) I2, imid, PPh3, Et2O/CH3CN, 83%; g) CuBr·DMS, CH2=CHMgBr, HMPA, THF, −25 °C, 84%; h) TBAF, THF, 0 °C, 90%.